Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition

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dc.contributor.authorVerri, V.
dc.contributor.authorBrandão, A.A.
dc.contributor.authorTibirica, E.
dc.date.accessioned2025-07-29T18:18:20Z
dc.date.available2025-07-29T18:18:20Z
dc.date.issued2018
dc.description.abstractThe primary aim of this study was to evaluate penile endothelial microvascular function in patients with primary arterial hypertension and age-matched normotensive subjects using laser speckle contrast imaging (LSCI). Additionally, we analyzed the acute penile microvascular effects induced by oral phosphodiesterase type 5 inhibitor (sildenafil; SIL) administration. Endothelium-dependent microvascular reactivity was evaluated in the penises and forearms of hypertensive patients (aged 58.8±6.6 years, n=34) and age-matched healthy volunteers (n=33) at rest and 60 min following oral SIL (100 mg) administration. LSCI was coupled with cutaneous acetylcholine (ACh) iontophoresis using increasing anodal currents. Basal penile cutaneous vascular conductance (CVC) values were not significantly different between control subjects and hypertensive individuals. Penile CVC values increased significantly after SIL administration in control (Po0.0001) and hypertensive (Po0.0001) subjects. Peak CVC values were not different between the two groups during penile ACh iontophoresis before SIL administration (P=0.2052). Peak CVC values were higher in control subjects than in hypertensive subjects after SIL administration (P=0.0427). Penile endothelium-dependent microvascular function is, to some extent, preserved in patients presenting with primary arterial hypertension under effective anti-hypertensive treatment. LSCI may be a valuable non-invasive tool for the evaluation of penile vascular responses to phosphodiesterase type 5 inhibitor.
dc.identifier.citationVerri V, Brandão AA, Tibirica E. Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition. Braz J Med Biol Res. 2018 Jan 11;51(3):e6601. doi: 10.1590/1414-431X20176601.
dc.identifier.otherDOI: 10.1590/1414-431X20176601
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/921
dc.language.isoen
dc.publisherBrazilian Journal of Medical and Biological Research
dc.subjectMicrovascular dysfunctionen
dc.subjectHypertensionen
dc.subjectLaser speckle contrast imagingen
dc.subjectPenile microcirculation.en
dc.titlePenile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
dc.typeArticle
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