XAF1 expression levels in a non-small cell lung cancer cohort and its potential association with carcinogenesis

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dc.contributor.authorSchluckebier, Luciene
dc.contributor.authorAran, Veronica
dc.contributor.authorMoraes, Joyce de
dc.contributor.authorPaiva, Heitor
dc.contributor.authorSternberg, Cinthya
dc.contributor.authorFerreira, Carlos Gil
dc.date.accessioned2024-10-08T17:17:19Z
dc.date.available2024-10-08T17:17:19Z
dc.date.issued2017
dc.description.abstractAbstract. The process of lung carcinogenesis is still not well understood and involves different levels of regulation of several genes. The search for molecular biomarkers, which can be applicable to clinical practice, has been the focus of various studies. XIAP-associated factor 1 (XAF1) was previ- ously shown to be downregulated in many types of tumors, including squamous cell lung cancer. XAF1 is a pro-apoptotic protein and its restoration was found to sensitize cancer cells to apoptotic stimuli; however, the precise mechanism involved in the downregulation of XAF1 in tumors is unknown and promoter hypermethylation or heat-shock transcription factor 1 (HSF1) may be involved. Therefore, the aim of the present study was to evaluate the expression of XAF1 in tumors and adjacent non-tumor specimens from non-small cell lung cancer (NSCLC) patients, and its potential association with various factors including clinicopathological characteristics and other genes involved in NSCLC. Our results indicated that XAF1 expression was markedly altered in NSCLC tumor samples when compared to that found in normal lung tissues. Predominantly, XAF1 was downregulated in the tumors, except in never-smoker patients. In addition, XAF1 may also be important in the whole cell stress mechanism where the p53 status is crucial.
dc.identifier.citationSchluckebier L, Aran V, De Moraes J, Paiva H, Sternberg C, Ferreira CG. XAF1 expression levels in a non-small cell lung cancer cohort and its potential association with carcinogenesis. Oncol Rep. 2017 Jul;38(1):402-410. doi: 10.3892/or.2017.5680.
dc.identifier.otherDOI: 10.3892/or.2017.5680.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/477
dc.language.isoen
dc.publisherOncology Reports
dc.subjectlung canceren
dc.subjectXIAP-associated factor 1en
dc.subjecthumanen
dc.subjectgenesen
dc.subjectp53en
dc.subjectp53, heat shock transcription factor 1en
dc.subjectcarcinogenesisen
dc.titleXAF1 expression levels in a non-small cell lung cancer cohort and its potential association with carcinogenesis
dc.typeArticle
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