Clinical Features and Treatment Outcomes of Patients with Drug-Resistant and Drug- Sensitive Tuberculosis: A Historical Cohort Study in Porto Alegre, Brazil

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dc.contributor.authorMicheletti, Vania Celina Dezoti
dc.contributor.authorKritski, Afrânio Lineu
dc.contributor.authorBraga, José Ueleres
dc.date.accessioned2024-11-25T18:38:28Z
dc.date.available2024-11-25T18:38:28Z
dc.date.issued2016
dc.description.abstractPurpose To evaluate the clinical features and treatment outcomes of patients with pulmonary tuber- culosis, stratified by level of drug resistance. Methods This was a historical cohort study based on data from the II National Anti-Tuberculosis Drug Resistance Survey (2006–2007) collected at eight participating health care facilities in Porto Alegre, southern Brazil. The cohort was followed for 3 years after the start of treatment. Results Of 299 cases of smear-positive pulmonary tuberculosis included in the study, 216 (72.2%) were diagnosed at five public primary health care units and 83 (27.8%) at three public hospi- tals. Among these cases, the prevalence of drug-resistant tuberculosis was 14.4%, and that of multidrug-resistant tuberculosis was 4.7%. Overall, 32.0% of drug-resistant and 2.0% of multidrug-resistant cases occurred in previously treated patients. The most common comor- bidity in the sample was HIV infection (26.2%). There was no association between drug- resistant or multidrug-resistant tuberculosis and sociodemographic variables. Cure was achieved in 66.7% of patients, and the default rate was 21.2%. The 2-month sputum conver- sion rate was 34.2%, and the relapse rate was 16.9%. Patients with drug-resistant tubercu- losis had lower rates of cure (45.2%) and 2-month sputum conversion (25%), as well as a higher relapse rate (30.7%). Conclusion These results highlight the urgent need for a more effective TB control program in this geo- graphical setting, with a major emphasis on treatment of drug-resistant and multidrug-resis- tant tuberculosis.
dc.identifier.citationMicheletti VC, Kritski AL, Braga JU. Clinical Features and Treatment Outcomes of Patients with Drug-Resistant and Drug-Sensitive Tuberculosis: A Historical Cohort Study in Porto Alegre, Brazil. PLoS One. 2016 Aug 9;11(8):e0160109. doi: 10.1371/journal.pone.0160109.
dc.identifier.otherDOI: 10.1371/journal.pone.0160109
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/624
dc.language.isoen
dc.publisherPLOS ONE
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntitubercular Agents / pharmacologyen
dc.subjectAntitubercular Agents / therapeutic use*en
dc.subjectBrazil / epidemiologyen
dc.subjectCohort Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectSurveys and Questionnairesen
dc.subjectTreatment Outcomeen
dc.subjectTuberculosis, Multidrug-Resistant / drug therapy*en
dc.subjectTuberculosis, Pulmonary / drug therapy*.en
dc.titleClinical Features and Treatment Outcomes of Patients with Drug-Resistant and Drug- Sensitive Tuberculosis: A Historical Cohort Study in Porto Alegre, Brazil
dc.typeArticle
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