Dietary supplementation with whey protein improves systemic microvascular function in heart failure patients: a pilot study
Dietary supplementation with whey protein improves systemic microvascular function in heart failure patients: a pilot study
Data
2021
Autores
Lorenzo, A. De
Santos, E.M. Dos
Moreira, A.S. Bello
Huguenin, G.V.B.
Tibirica, E.
Journal Title
Journal ISSN
Volume Title
Publisher
Brazilian Journal of Medical and Biological Research
Resumo
Endothelial dysfunction is a well-known component of the pathophysiology of heart failure (HF), with proven prognostic value.
Dietary supplementation with whey protein (WP) has been widely used to increase skeletal muscle mass, but it also has
vascular effects, which are less understood. This study aimed to evaluate the effects of WP supplementation on the systemic
microvascular function of HF patients. This was a blinded, randomized, placebo-controlled clinical trial that evaluated the effects
of 12-week WP dietary supplementation on systemic microvascular function, in patients with HF New York Heart Association
(NYHA) classes I/II. Cutaneous microvascular flow and reactivity were assessed using laser speckle contrast imaging, coupled
with pharmacological local vasodilator stimuli. Fifteen patients (aged 64.5±6.2 years, 11 males) received WP supplementation
and ten patients (aged 68.2±8.8 years, 8 males) received placebo (maltodextrin). The increase in endothelial-dependent
microvascular vasodilation, induced by skin iontophoresis of acetylcholine, was improved after WP (P=0.03) but not placebo
(P=0.37) supplementation. Moreover, endothelial-independent microvascular vasodilation induced by skin iontophoresis of
sodium nitroprusside, was also enhanced after WP (P=0.04) but not placebo (P=0.42) supplementation. The results suggested
that dietary supplementation with WP improved systemic microvascular function in patients with HF.
Description
Palavras-chave
Laser speckle contrast imaging, Microvascular reactivity, Endothelial function, Dietary supplementation, Skin iontophoresis.
Citação
Lorenzo A, Santos EMD, Bello Moreira AS, Huguenin GVB, Tibirica E. Dietary supplementation with whey protein improves systemic microvascular function in heart failure patients: a pilot study. Braz J Med Biol Res. 2021 Apr 19;54(6):e10577. doi: 10.1590/1414-431X202010577.