Active and latent tuberculosis in refugees and asylum seekers: a systematic review and meta-analysis

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dc.contributor.authorProença, Raquel
dc.contributor.authorSouza, Fernanda Mattos
dc.contributor.authorBastos, Mayara Lisboa
dc.contributor.authorCaetano, Rosângela
dc.contributor.authorBraga, José Ueleres
dc.contributor.authorFaerstein, Eduardo
dc.contributor.authorTrajman, Anete
dc.date.accessioned2024-12-05T17:31:22Z
dc.date.available2024-12-05T17:31:22Z
dc.date.issued2020
dc.description.abstractBackground: In 2018, there were 70.8 million refugees, asylum seekers and persons displaced by wars and conflicts worldwide. Many of these individuals face a high risk for tuberculosis in their country of origin, which may be accentuated by adverse conditions endured during their journey. We summarised the prevalence of active and latent tuberculosis infection in refugees and asylum seekers through a systematic literature review and meta- analyses by country of origin and host continent. Methods: Articles published in Medline, EMBASE, Web of Science and LILACS from January 2000 to August 2017 were searched for, without language restriction. Two independent authors performed the study selection, data extraction and quality assessment. Random effect models were used to estimate average measures of active and latent tuberculosis prevalence. Sub-group meta-analyses were performed according to country of origin and host continent. Results: Sixty-seven out of 767 identified articles were included, of which 16 entered the meta-analyses. Average prevalence of active and latent tuberculosis was 1331 per 100 thousand inhabitants [95% confidence interval (CI) = 542–2384] and 37% (95% CI = 23–52%), respectively, both with high level of heterogeneity (variation in estimative attributable to heterogeneity [I2 ] = 98.2 and 99.8%). Prevalence varied more according to countries of origin than host continent. Ninety-one per cent of studies reported routine screening of recently arrived immigrants in the host country; two-thirds confirmed tuberculosis bacteriologically. Many studies failed to provide relevant information. Conclusion: Tuberculosis is a major health problem among refugees and asylum seekers and should be given special attention in any host continent. To protect this vulnerable population, ensuring access to healthcare for early detection for prevention and treatment of the disease is essential.
dc.identifier.citationProença R, Mattos Souza F, Lisboa Bastos M, Caetano R, Braga JU, Faerstein E, Trajman A. Active and latent tuberculosis in refugees and asylum seekers: a systematic review and meta-analysis. BMC Public Health. 2020 Jun 3;20(1):838. doi: 10.1186/s12889-020-08907-y.
dc.identifier.otherDOI: 10.1186/s12889-020-08907-y
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/665
dc.language.isoen
dc.publisherBMC Public Health
dc.subjectForced migrationen
dc.subjectMycobacterium tuberculosisen
dc.subjectLatent tuberculosis infectionen
dc.subjectPrevalenceen
dc.subjectGlobal healthen
dc.titleActive and latent tuberculosis in refugees and asylum seekers: a systematic review and meta-analysis
dc.typeArticle
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