Mortality Predictors in Patients with Severe Dengue in the State of Amazonas, Brazil

Página do item simplificado
dc.contributor.authorPinto, Rosemary Costa
dc.contributor.authorCastro, Daniel Barros de
dc.contributor.authorAlbuquerque, Bernardino Cláudio de
dc.contributor.authorSampaio, Vanderson de Souza
dc.contributor.authorPassos, Ricardo Augusto dos
dc.contributor.authorCosta, Cristiano Fernandes da
dc.contributor.authorSadahiro, Megumi
dc.contributor.authorBraga, José Ueleres
dc.date.accessioned2024-11-25T19:43:23Z
dc.date.available2024-11-25T19:43:23Z
dc.date.issued2016
dc.description.abstractDengue is a major public health problem in tropical and subtropical areas worldwide. There is a lack of information on the risk factors for death due to severe dengue fever in developing countries, including Brazil where the state of Amazonas is located. This knowledge is impor- tant for decision making and the implementation of effective measures for patient care. This study aimed to identify factors associated with death among patients with severe dengue, in Amazonas from 2001 to 2013. We conducted a retrospective cohort study based on sec- ondary data from the epidemiological surveillance of dengue provided by the Fundação de Vigilância em Saúde do Amazonas, FVS (Health Surveillance Foundation) of the Secretaria de Saúde do Amazonas, SUSAM (Health Secretariat of the State of Amazonas). Data on dengue cases were obtained from the SINAN (Notifiable Diseases Information System) and SIM (Mortality Information System) databases. We selected cases of severe dengue with laboratory confirmation, including dengue-related deaths of residents in the state of Amazo- nas from January 1, 2001, to December 31, 2013. The explanatory variables analyzed were sex, age, level of education, spontaneous hemorrhagic manifestations, plasma extravasa- tion and platelet count. Patients who died due to severe dengue had more hematuria, gas- trointestinal bleeding, and thrombocytopenia than the survivors. Considering the simultaneous effects of demographic and clinical characteristics with a multiple logistic regression model, it was observed that the factors associated with death were age >55 years (odds ratio [OR] 4.98), gastrointestinal bleeding (OR 10.26), hematuria (OR 5.07), and thrombocytopenia (OR 2.55). Gastrointestinal bleeding was the clinical sign most strongly associated with death, followed by hematuria and age >55 years. The study results showed that the best predictor of death from severe dengue is based on the characteristic of age >55 years, together with the clinical signs of gastrointestinal bleeding, hematuria, and low platelet count.
dc.identifier.citationPinto RC, Castro DB, Albuquerque BC, Sampaio Vde S, Passos RA, Costa CF, Sadahiro M, Braga JU. Mortality Predictors in Patients with Severe Dengue in the State of Amazonas, Brazil. PLoS One. 2016 Aug 26;11(8):e0161884. doi: 10.1371/journal.pone.0161884.
dc.identifier.otherDOI: 10.1371/journal.pone.0161884
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/627
dc.language.isoen
dc.publisherPLOS ONE
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectBrazil / epidemiologyen
dc.subjectDisease Outbreaksen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLogistic Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOdds Ratioen
dc.subjectRetrospective Studiesen
dc.subjectRisk Factorsen
dc.subjectSevere Dengue / epidemiology*en
dc.subjectSevere Dengue / mortality*en
dc.subjectSeverity of Illness Indexen
dc.subjectYoung Adulten
dc.titleMortality Predictors in Patients with Severe Dengue in the State of Amazonas, Brazil
dc.typeArticle
Arquivos
Original bundle
Agora exibindo 1 - 1 de 1
thumbnail.default.alt
Nome:
Pinto MC et al_PLOS One.pdf
Tamanho:
257.34 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
License bundle
Agora exibindo 1 - 1 de 1
thumbnail.default.placeholder
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed to upon submission
Descrição:
Baixar
Coleções
Produção Docente