B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation

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dc.contributor.authorBassan, Roberto
dc.contributor.authorPotsch, Alfredo
dc.contributor.authorMaisel, Alan
dc.contributor.authorTura, Bernardo
dc.contributor.authorVillacorta, Humberto
dc.contributor.authorNogueira, Mônica Viegas
dc.contributor.authorCampos, Augusta
dc.contributor.authorGamarski, Roberto
dc.contributor.authorMasetto, Antonio Cláudio
dc.contributor.authorMoutinho, Marco Aurélio
dc.date.accessioned2024-02-01T14:20:02Z
dc.date.available2024-02-01T14:20:02Z
dc.date.issued2005
dc.description.abstractAims: This study was undertaken to determine the diagnostic value of admission B-type natriuretic peptide (BNP) for acute myocardial infarction (AMI) in patients with acute chest pain and no ST-segment elevation. Methods and results: A prospective study with 631 consecutive patients was conducted in the emergency department. Non-ST elevation AMI was present in 72 patients and their median admission BNP level was significantly higher than in unstable angina and non-acute coronary syndrome patients. Sensitivity of admission BNP for AMI (cut-off value of 100 pg/mL) was significantly higher than creatine kinase-MB (CKMB) and troponin-I on admission (70.8 vs. 45.8 vs. 50.7%, respectively, P<0.0001) and specificity was 68.9%. Simultaneous use of these markers significantly improved sensitivity to 87.3% and the negative predictive value to 97.3%. In multiple logistic regression analysis, admission BNP was a significant independent predictor of AMI, even when CKMB and troponin-I were present in the model. Conclusion: BNP is a useful adjunct to standard cardiac markers in patients presenting to the emergency department with chest pain and no ST-segment elevation, particularly if initial CKMB and/or troponin-I are non-diagnostic.
dc.identifier.citationBassan R, Potsch A, Maisel A, Tura B, Villacorta H, Nogueira MV, Campos A, Gamarski R, Masetto AC, Moutinho MA. B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation. Eur Heart J. 2005 Feb;26(3):234-40. doi: 10.1093/eurheartj/ehi033.
dc.identifier.otherDOI: 10.1093/eurheartj/ehi033
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/395
dc.language.isoen
dc.publisherEuropean Heart Journal
dc.titleB-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation
dc.typeArticle
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