Proteomics of cell–cell interactions in health and disease

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dc.contributor.authorLindoso, Rafael S.
dc.contributor.authorSandim, Vanessa
dc.contributor.authorCollino, Federica
dc.contributor.authorCarvalho, Adriana B.
dc.contributor.authorDias, Juliana
dc.contributor.authorCosta, Milene R. da
dc.contributor.authorZingali, Russolina B.
dc.contributor.authorVieyra, Adalberto
dc.date.accessioned2024-11-01T17:13:51Z
dc.date.available2024-11-01T17:13:51Z
dc.date.issued2016
dc.description.abstractThe mechanisms of cell–cell communications are now under intense study by proteomic ap- proaches. Proteomics has unraveled changes in protein profiling as the result of cell interactions mediated by ligand/receptor, hormones, soluble factors, and the content of extracellular vesi- cles. Besides being a brief overview of the main and profitable methodologies now available (evaluating theory behind the methods, their usefulness, and pitfalls), this review focuses on— from a proteome perspective—some signaling pathways and post-translational modifications (PTMs), which are essential for understanding ischemic lesions and their recovery in two vital organs in mammals, the heart, and the kidney. Knowledge of misdirection of the proteome during tissue recovery, such as represented by the convergence between fibrosis and cancer, emerges as an important tool in prognosis. Proteomics of cell–cell interaction is also espe- cially useful for understanding how stem cells interact in injured tissues, anticipating clues for rational therapeutic interventions. In the effervescent field of induced pluripotency and cell reprogramming, proteomic studies have shown what proteins from specialized cells contribute to the recovery of infarcted tissues. Overall, we conclude that proteomics is at the forefront in helping us to understand the mechanisms that underpin prevalent pathological processes.
dc.identifier.citationLindoso RS, Sandim V, Collino F, Carvalho AB, Dias J, da Costa MR, Zingali RB, Vieyra A. Proteomics of cell-cell interactions in health and disease. Proteomics. 2016 Jan;16(2):328-44. doi: 10.1002/pmic.201500341.
dc.identifier.otherDOI: 10.1002/pmic.201500341
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/580
dc.language.isoen
dc.publisherProteomics
dc.subjectCell biologyen
dc.subjectCell communicationen
dc.subjectCell signalingen
dc.subjectExtracellular vesiclesen
dc.subjectProteomic modelsen
dc.subjectSecretomeen
dc.titleProteomics of cell–cell interactions in health and disease
dc.typeArticle
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