Novel tests for diagnosing tuberculous pleural effusion: what works and what does not?
Novel tests for diagnosing tuberculous pleural effusion: what works and what does not?
Data
2008
Autores
Trajman, A.
Pai, M.
Dheda, K.
van Zyl Smit, R.
Zwerling, A.A.
Joshi, R.
Kalantri, S.
Daley, P.
Menzies, D.
Journal Title
Journal ISSN
Volume Title
Publisher
The European Respiratory Journal
Resumo
Tuberculous pleuritis is a common manifestation of extrapulmonary tuberculosis and
is the most common cause of pleural effusion in many countries. Conventional diagnostic tests,
such as microscopic examination of the pleural fluid, biochemical tests, culture of pleural fluid,
sputum or pleural tissue, and histopathological examination of pleural tissue, have known
limitations. Due to these limitations, newer and more rapid diagnostic tests have been evaluated.
In this review, the authors provide an overview of the performance of new diagnostic tests,
including markers of specific and nonspecific immune response, nucleic acid amplification and
detection, and predictive models based on combinations of markers. Directions for future
development and evaluation of novel assays and biomarkers for pleural tuberculosis are also
suggested.
Description
Palavras-chave
Biomarkers, diagnosis, pleuritis, sensitivity, specificity, tuberculosis.
Citação
Trajman A, Pai M, Dheda K, van Zyl Smit R, Zwerling AA, Joshi R, Kalantri S, Daley P, Menzies D. Novel tests for diagnosing tuberculous pleural effusion: what works and what does not? Eur Respir J. 2008 May;31(5):1098-106. doi: 10.1183/09031936.00147507.