Coronary atherosclerosis and periodontitis have similarities in their clinical presentation
Coronary atherosclerosis and periodontitis have similarities in their clinical presentation
Data
2024
Autores
Mattos, Marcelo Barbosa De Accioly
Peixoto, Camila Bernardo
Amino, José Geraldo de Castro
Cortes, Leandro
Tura, Bernardo
Nunn, Martha
Giambiagi-deMarval, Marcia
Sansone, Carmelo
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers in Oral Health
Resumo
Background: Periodontitis (PE) and coronary heart disease (CHD) possess multiple
mechanisms for a putative association. This case-control study compared the
periodontal status among CHD subjects to controls without CHD, while also
investigating atheroma invasion by known periodontal pathogens.
Methods: 161 subjects participated in this study were divided into three CHD
groups: No CHD, chronic CHD, acute CHD. Additional analysis involved grouping
subjects according to number of atheromas: no atheroma, 1–4 atheromas, 5–18
atheromas. Data were collected from medical records, periodontal examinations,
and questionnaires that included demographic, behavioral, and oral health
variables. Angiographic catheterizations were analyzed according to the number
of atheroma lesions, lesion size, lesion location, and atheroma lesion stability.
Lipoprotein profile, inflammatory markers and cells were analyzed. The
microbiological branch added 30 individuals who had their atheroma lesion and
subgingival plaque analyzed using polymerase chain reaction probes against the
16 s region, red complex and Aggregatibacter actinomycetemcomitans’ DNA.
Results: Subjects with CHD had high levels of systemic inflammatorymarkers and low
levels of high-density lipoproteins compared to subjects without CHD. Subjects
without CHD and clear coronaries had a prevalence of mild CAL, while individuals
with more atheroma lesions had advanced CAL and more active PE. Subjects with
more advanced CAL were 4 times more likely to have CHD compared to subjects
with less, which is comparable to smoking. Only 4 subjects had the screened
pathogens detected in atheroma, although these subjects also have the screened
pathogens in subgingival plaque. However, 80% of atheromas had bacteria.
Conclusions: CHD and PE showed similarities in progression while active PE led to
more atheroma lesions that also tended to be larger in size.
Description
Palavras-chave
Periodontitis, coronary heart disease, atherosclerosis, atheroma burden, inflammation.
Citação
Migowski A, Nadanovsky P, Manso de Mello Vianna C. Harms and benefits of mammographic screening for breast cancer in Brazil. PLoS One. 2024 Jan 25;19(1):e0297048. doi: 10.1371/journal.pone.0297048.