Seção de Ensino

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Navegando Seção de Ensino por Autor "Abreu, S. T. de"

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    Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
    (International Journal of Tuberculosis and Lung Disease, 2013) Bastos, M. L.; Menzies, D.; Belo, M. T. C. T.; Teixeira, E. G.; Abreu, S. T. de; Antas, P. R. Z.
    SETTING: Randomised trial comparing 9 months of isoniazid with 4 months of rifampicin for the treatment of high-risk tuberculin skin test positive subjects in Rio de Janeiro, Brazil. OBJECTIVES: To compare QuantiFERON®-TB Gold In- Tube (QFT-GIT) responses before and 1, 4 and 9 months after starting treatment for latent tuberculous infection (LTBI) according to adherence to one of the two regimens. DESIGN: Participants in the trial were invited to under- go serial QFT-GIT. Within-subject differences at differ- ent time points were analysed as quantitative responses and categorised as positive or negative using different cut-off points. RESULTS: Of 215 participants, 118 completed treat- ment, of whom 58 underwent all three tests; and 97 did not complete treatment, of whom 10 underwent all tests. After 1 month of treatment, there was no significant dif- ference in QFT-GIT response between the groups. After 4 and 9 months, reversions were more frequent in non- adherent subjects. Marked within-subject fluctuations were observed. No cut-off point could be established at which QFT-GIT responses were consistently positive or associated with adherence or type of treatment. CONCLUSION: Frequent within-subject variability in QFT-GIT responses, not associated with LTBI treatment, makes it difficult for clinicians to interpret QFT-GIT conversions and reversions.