Reduced systemic microvascular density and reactivity in individuals with early onset coronary artery disease

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dc.contributor.authorTibiriça, Eduardo
dc.contributor.authorSouza, Elaine G
dc.contributor.authorDe Lorenzo, Andrea
dc.contributor.authorOliveira, Glaucia M.M.
dc.date.accessioned2022-09-14T17:55:20Z
dc.date.available2022-09-14T17:55:20Z
dc.date.issued2015
dc.description.abstractObjective: This study sought to test whether patients with early-onset coronary artery disease (EOCAD, n=30) showed systemic microvascular rarefaction and endothelial dysfunction in comparison to age- and sex-matched healthy controls (CTL, n = 30), as evaluated by skin video-capillaroscopy. Methods: Functional capillary density (FCD)was defined as the number of spontaneously perfused capillaries per square millimeter of skin area and assessed by high-resolution intra-vital color microscopy in the dorsum of the middle phalanx. Capillary recruitment (capillary reserve)was evaluated using post-occlusive reactive hyperemia (PORH) after arm ischemia for 3 min. Results: The mean capillary density at restwas significantly reduced in patientswith EOCADcompared to controls (CTL 95±20 and EOCAD 80±18 capillaries/mm2, P= 0.0040). During PORH, capillary density was also markedly reduced in EOCAD patients (CTL 96 ± 18 and EOCAD 71 ± 20 capillaries/mm2, P b 0.0001). Moreover, the capillary density in EOCAD patients was significantly reduced during PORH (EOCAD at rest 80± 19 and EOCAD during PORH 71 ± 20 capillaries/mm2, P = 0.0073). Conclusions: Patientswith EOCAD presented systemic capillary rarefaction and impaired microvascular endothelial function. Thus, the early detection of these microvascular alterations in young adults at an increased risk of coronary artery disease could be useful as a surrogate marker of subclinical atherosclerosis.en
dc.identifier.citationTibiriçá E, Souza EG, De Lorenzo A, Oliveira GMM. Reduced systemic microvascular density and reactivity in individuals with early onset coronary artery disease. Microvascular Research. 2015;97:105-8.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/286
dc.language.isoen
dc.publisherMicrovascular Research
dc.subjectSkin microvascular reactivityen
dc.subjectMicrovascular endothelial dysfunctionen
dc.subjectCoronary artery diseaseen
dc.subjectCapillary rarefactionen
dc.subjectCardiovascular risken
dc.subject.meshSkin / blood supplyen
dc.subject.meshPredictive Value of Testsen
dc.subject.meshMiddle Ageden
dc.subject.meshMicrovessels / physiopathologyen
dc.subject.meshMicrovessels / pathologyen
dc.subject.meshMicroscopy, Videoen
dc.subject.meshMicroscopic Angioscopy / methodsen
dc.subject.meshMicrocirculationen
dc.subject.meshMaleen
dc.subject.meshHyperemia / physiopathologyen
dc.subject.meshHumansenq
dc.subject.meshFemaleen
dc.subject.meshEndothelium, Vascular / physiopathologyen
dc.subject.meshEndothelium, Vascular / pathologyen
dc.subject.meshEarly Diagnosisen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshCoronary Artery Disease / physiopathologyen
dc.subject.meshCoronary Artery Disease / diagnosisen
dc.subject.meshCase-Control Studiesen
dc.subject.meshAge of Onseten
dc.subject.meshAdulten
dc.titleReduced systemic microvascular density and reactivity in individuals with early onset coronary artery diseaseen
dc.typeArticle
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