Efects of mixed nuts as part of a Brazilian Cardioprotective diet on LDL‐cholesterol in adult patients after myocardial infarction: a multicenter randomized controlled clinical trial

Página do item simplificado
dc.contributor.authorBersch-Ferreira, Ângela Cristine
dc.contributor.authorWeschenfelder, Camila
dc.contributor.authorMachado, Rachel Helena Vieira
dc.contributor.authorSantos, Renato Hideo Nakagawa
dc.contributor.authorRiley, Terrence M.
dc.contributor.authorMoreira, Annie Seixas Bello
dc.date.accessioned2025-01-28T14:44:26Z
dc.date.available2025-01-28T14:44:26Z
dc.date.issued2024
dc.description.abstractBackground: Nuts consumption is related to cardioprotective effects on primary cardiovascular prevention, but studies conducted in secondary prevention are small, scarce and controversial. The objective of this trial was to evaluate the effects of a regional and sustainable cardioprotective diet added or not with an affordable mixed nuts on cardiometabolic features in patients with previous myocardial infarction. Methods: DICA-NUTS study is a national, multi-center, and superiority-parallel randomized clinical trial. Males and females over 40 years old diagnosed with previous myocardial infarction in the last 2 to 6 months were included. Patients were allocated into two groups: the Brazilian Cardioprotective diet (DICA Br) supplemented with 30 g/day of mixed nuts (10 g of peanuts; 10 g of cashew; 10 g of Brazil nuts) (intervention group, n = 193); or only DICA Br prescription (control group, n = 195). The primary outcome was low-density lipoprotein cholesterol means (in mg/dL) after 16 weeks. Secondary outcomes were other lipid biomarkers, glycemic and anthropometric data and diet quality. Results: After adjustment for baseline values, participating study site, time since myocardial infarction and statin treatment regimen (high potency, moderate and low potency/no statins), no significant difference was found between the groups in low-density lipoprotein cholesterol concentrations (intervention-control difference: 3.48 mg/dL [-3.45 to 10.41], P = 0.32). Both groups improved their overall diet quality at the end of the study without differences between them after 16 weeks (intervention-control difference: 1.05 (-0.9 to 2.99); P = 0.29). Other lipids, glycemic profile and anthropometrics were also not different between study groups at the end of the study. Conclusion: Adding 30 g/day of mixed nuts to the DICA Br for 16 weeks did not change lipid, glycemic and anthropometric features in the post-myocardial infarction setting. Trial registration: This study is registered on ClinicalTrials.gov website under number NCT03728127 and its World Health Organization Universal Trial Number (WHO-UTN) is U1111-1259-8105.
dc.identifier.citationBersch-Ferreira ÂC, Weschenfelder C, Vieira Machado RH, Nakagawa Santos RH, Riley TM, Moreira ASB et al. Effects of mixed nuts as part of a Brazilian Cardioprotective diet on LDL-cholesterol in adult patients after myocardial infarction: a multicenter randomized controlled clinical trial. Nutr J. 2024 Oct 1;23(1):118. doi: 10.1186/s12937-024-01020-5.
dc.identifier.otherDOI: 10.1186/s12937-024-01020-5
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/761
dc.language.isoen
dc.publisherNutrition Journal
dc.subjectMyocardial Infarctionen
dc.subjectDieten
dc.subjectHealthyen
dc.subjectNutsen
dc.subjectCholesterolen
dc.subjectLDLen
dc.subjectRandomized Controlled Trial [Publication Type].en
dc.titleEfects of mixed nuts as part of a Brazilian Cardioprotective diet on LDL‐cholesterol in adult patients after myocardial infarction: a multicenter randomized controlled clinical trial
dc.typeArticle
Arquivos
Original bundle
Agora exibindo 1 - 1 de 1
thumbnail.default.alt
Nome:
Bersch-Ferreira AC et al_Nutrition Journal.pdf
Tamanho:
1.55 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
License bundle
Agora exibindo 1 - 1 de 1
thumbnail.default.placeholder
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed to upon submission
Descrição:
Baixar
Coleções
Artigos