Microvascular Function and Endothelial Progenitor Cells in Patients with Severe Hypercholesterolemia and the Familial Hypercholesterolemia Phenotype

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dc.contributor.authorDe Lorenzo, Andrea
dc.contributor.authorMoreira, Annie S B
dc.contributor.authorMuccillo, Fabiana B
dc.contributor.authorAssad, Marcelo
dc.contributor.authorTibiriƧƔ, Eduardo V
dc.date.accessioned2022-09-12T16:56:08Z
dc.date.available2022-09-12T16:56:08Z
dc.date.issued2017
dc.description.abstractObjective: To evaluate endothelial progenitor cells (EPCs) and systemic microvascular function in patients with severe hypercholesterolemia, comparing patients with the definite familial hypercholesterolemia (FH) phenotype (DFH) or probable/possible FH phenotype (PFH). There is a large spectrum of atherosclerotic disease between these two clinical phenotypes of FH, and to acquire further knowledge of the pathophysiology of vascular disease in both is desirable. Methods: Subjects with severe hypercholesterolemia, defined as low-density lipoprotein cholesterol (LDL-C) >190 mg/dL, were classified as DFH or PFH and underwent measurement of the number of EPCs by flow cytometry and evaluation of cutaneous microvascular reactivity using a laser speckle contrast-imaging system with iontophoresis of acethylcholine (ACh) or sodium nitroprusside. EPCs were defined as CD45- or CD45low, CD34+CD133+CD309+ cells. Categorical variables were compared using Fisher test and continuous variables with Student t test or Mann-Whitney test, and a value of p < 0.05 was considered statistically significant. Results: Patients with DFH had higher LDL-C than those with PFH. There was no difference in the median number of EPCs between patients with DFH or PFH, but there was a significant reduction of endothelial-dependent, ACh-induced vasodilatation in the former. Conclusion: Patients with DFH have impaired microvascular endothelial-dependent vasodilatation compared to those with PFH, indicating more severe vascular disease in the former.
dc.identifier.citationDe Lorenzo A, Moreira ASB, Muccillo FB, Assad M, Tibirica EV. Microvascular Function and Endothelial Progenitor Cells in Patients with Severe Hypercholesterolemia and the Familial Hypercholesterolemia Phenotype. Cardiology. 2017;137(4):231-236.
dc.identifier.doiDOI: 10.1159/000470829
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/246
dc.language.isoen
dc.publisherCardiology
dc.subjectFamilial hypercholesterolemiaen
dc.subjectEndothelial progenitor cellsen
dc.subjectEndothelial functionen
dc.subjectMicrovascular functionen
dc.subject.meshVasodilationen
dc.subject.meshProspective Studiesen
dc.subject.meshPhenotypeen
dc.subject.meshMiddle Ageden
dc.subject.meshMaleen
dc.subject.meshHyperlipoproteinemia Type II / physiopathologyen
dc.subject.meshHypercholesterolemia / physiopathologyen
dc.subject.meshHumansen
dc.subject.meshFlow Cytometryen
dc.subject.meshFemaleen
dc.subject.meshEndothelium, Vascular / physiopathologyen
dc.subject.meshEndothelial Progenitor Cells / cytologyen
dc.subject.meshCholesterol, LDL / blooden
dc.subject.meshAgeden
dc.subject.meshAdulten
dc.titleMicrovascular Function and Endothelial Progenitor Cells in Patients with Severe Hypercholesterolemia and the Familial Hypercholesterolemia Phenotypeen
dc.typeArticle
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