Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort

Página do item simplificado
dc.contributor.authorFernández Hidalgo, Núria
dc.contributor.authorGharamti, Amal A
dc.contributor.authorAznar, María Luisa
dc.contributor.authorAlmirante, Benito
dc.contributor.authorYasmin, Mohamad
dc.contributor.authorFortes, Claudio Querido
dc.contributor.authorPlesiat, Patrick
dc.contributor.authorDoco-Lecompte, Thanh
dc.contributor.authorRizk, Hussein
dc.contributor.authorWray, Dannah
dc.contributor.authorLamas, Cristiane
dc.contributor.authorDurante-Mangoni, Emanuele
dc.contributor.authorTattevin, Pierre
dc.contributor.authorSnygg-Martin, Ulrika
dc.contributor.authorHannan, Margaret M
dc.contributor.authorChu, Vivian H
dc.contributor.authorKanafani, Zeina A
dc.date.accessioned2022-09-09T12:59:12Z
dc.date.available2022-09-09T12:59:12Z
dc.date.issued2020
dc.description.abstractBackground: Beta-hemolytic streptococci (BHS) are an uncommon cause of infective endocarditis (IE). The aim of this study was to describe the clinical features and outcomes of patients with BHS IE in a large multinational cohort and compare them with patients with viridans streptococcal IE. Methods: The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) is a large multinational database that recruited patients with IE prospectively using a standardized data set. Sixty-four sites in 28 countries reported patients prospectively using a standard case report form developed by ICE collaborators. Results: Among 1336 definite cases of streptococcal IE, 823 were caused by VGS and 147 by BHS. Patients with BHS IE had a lower prevalence of native valve (P < .005) and congenital heart disease predisposition (P = .002), but higher prevalence of implantable cardiac device predisposition (P < .005). Clinically, they were more likely to present acutely (P < .005) and with fever (P = .024). BHS IE was more likely to be complicated by stroke and other systemic emboli (P < .005). The overall in-hospital mortality of BHS IE was significantly higher than that of VGS IE (P = .001). In univariate analysis, variables associated with in-hospital mortality for BHS IE were age (odds ratio [OR], 1.044; P = .004), prosthetic valve IE (OR, 3.029; P = .022), congestive heart failure (OR, 2.513; P = .034), and stroke (OR, 3.198; P = .009). Conclusions: BHS IE is characterized by an acute presentation and higher rate of stroke, systemic emboli, and in-hospital mortality than VGS IE. Implantable cardiac devices as a predisposing factor were more often found in BHS IE compared with VGS IE.
dc.identifier.citationFernández Hidalgo N, Gharamti AA, Aznar ML, Almirante B, Yasmin M, Fortes CQ et al. Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort. Open Forum Infect Dis. 2020;7(5):ofaa120.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/225
dc.language.isoen
dc.publisherOpen Forum Infectious Diseaes
dc.subjectBeta-hemolytic streptococcien
dc.subjectCardiac devicesen
dc.subjectCongestive heart failureen
dc.subjectInfective endocarditisen
dc.subjectInternational Collaboration on Endocarditisen
dc.titleBeta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohorten
dc.typeArticleen
Arquivos
Original bundle
Agora exibindo 1 - 1 de 1
thumbnail.default.alt
Nome:
Artigo_Fernandez Hidalgo N et al_2020.pdf
Tamanho:
4.2 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
License bundle
Agora exibindo 1 - 1 de 1
thumbnail.default.placeholder
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed to upon submission
Descrição:
Baixar
Coleções
Artigos Mestrado CC