Pneumococcal infective endocarditis in Brazil: a multicenter study on a severe condition

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dc.contributor.authorMamani, Roxana Flores
dc.contributor.authorSiciliano, Rinaldo Focaccia
dc.contributor.authorFortes, Claudio Querido
dc.contributor.authorDamasco, Paulo Vieria
dc.contributor.authorLamas, Cristiane da Cruz
dc.date.accessioned2025-01-28T14:56:43Z
dc.date.available2025-01-28T14:56:43Z
dc.date.issued2024
dc.description.abstractBackground: Streptococcus pneumoniae bacteremia may result in Infective Endocarditis (IE). In the pre-antibiotic era, it caused 10 %‒15 % of IE, decreasing to < 3 % after penicillin availability. Although infrequent, it causes aggressive disease. Methods: Retrospective analysis of endocarditis databases, prospectively implemented in 4 Brazilian institutions, 2005‒2023. Results: From the prospective cohorts comprising 2321 adult patients with IE, we identified 11 (0.47%) with pneumococcal IE. Males represented 7/11 and mean age was 54 years (22‒ 77). All had native valve involvement; perivalvular abscess was present in 6/11. Only one patient had concurrent meningitis. Beta-lactams were the antibiotics used in 10/11. All had surgical indication, but only 6 had it, as the others were seriously ill. Overall, in hospital mortality was 6/11, but only 1/6 of those who underwent surgery died, compared to 5/5 of those who had an indication for surgery and did not have it. Conclusions: The high mortality rates and need for surgical intervention emphasize the need to promptly identify and manage pneumococcal endocarditis. Physicians ought to recom- mend vaccination to all patients at risk for severe pneumococcal disease.
dc.identifier.citationMamani RF, Siciliano RF, Fortes CQ, Damasco PV, Lamas CDC. Pneumococcal infective endocarditis in Brazil: a multicenter study on a severe condition. Braz J Infect Dis. 2024 Jul-Aug;28(4):103837. doi: 10.1016/j.bjid.2024.103837.
dc.identifier.otherDOI: 10.1016/j.bjid.2024.103837
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/762
dc.language.isoen
dc.publisherThe Brazilian Journal of Jnfectious Diseases
dc.subjectStreptococcus pneumoniaeen
dc.subjectInfective endocarditisen
dc.subjectSurgeryen
dc.subjectMortality.en
dc.titlePneumococcal infective endocarditis in Brazil: a multicenter study on a severe condition
dc.typeArticle
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