Evaluation of myocardial contraction fraction in transcatheter aortic valve replacement
Evaluation of myocardial contraction fraction in transcatheter aortic valve replacement
Data
2024
Autores
Machado, Luana da Graça
Salgado, Angelo
Lorenzo, Andrea de
Journal Title
Journal ISSN
Volume Title
Publisher
Heart, Vessels and Transplantation
Resumo
Objective: Myocardial contraction fraction (MCF), a costless, easy-to-perform echocardiographic measure, which
estimates cardiac function through the volumetric measurement of myocardial shortening, may be a useful
prognostic indicator in patients undergoing transcatheter aortic valve replacement (TAVR). This study aimed to
evaluate MCF in patients who underwent TAVR at a public hospital in Rio de Janeiro, Brazil.
Methods: This was a retrospective cohort study. Clinical and echocardiographic data were obtained from medical
records. MCF was calculated as FDV in mL/FSV in mL x100, where FDV= final diastolic volume and FSV= final systolic
volume. These were derived from the dimensions of the left ventricle. The FDV was estimated as 4.5 x (final diastolic
diameter of the left ventricle) and the FSV was estimated as 3.72 x (final systolic diameter of the left ventricle).
Patients were followed for 66 months, and all-cause mortality was registered.
Results: Overall, 78 patients were studied. Median age was 78 years. Mortality was 56.4% over 9 years, with 29% of
deaths in the first year. Pre-TAVR median MCF (45.9%) was low, while mean left ventricular ejection fraction (LVEF)
was normal (57.0%). In patients who survived after the procedure, MCF increased post-TAVR, but in those who died,
it decreased (49.3% vs 45.1%).
Conclusions: MCF may demonstrate left ventricular dysfunction unrecognized by LVEF measurement in patients
undergoing TAVR, and may be a prognostic marker in this patient population.
Description
Palavras-chave
Transcatheter aortic valve replacement, aortic stenosis, myocardial contraction fraction, ventricular
function.
Citação
Machado LG, Salgado A, Lorenzo A. Evaluation of myocardial contraction fraction in transcatheter aortic valve replacement. Heart, Vessels and Transplantation. 2024;8(1):5. doi: 10.24969/hvt.2023.449.