Increased Preoperative C-Reactive Protein Levels Are Associated with Inhospital Death After Coronary Artery Bypass Surgery

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dc.contributor.authorDe Lorenzo, Andrea
dc.contributor.authorPittella, Felipe
dc.contributor.authorRocha, Antonio
dc.date.accessioned2022-09-14T16:45:37Z
dc.date.available2022-09-14T16:45:37Z
dc.date.issued2012
dc.description.abstractIncreased C-reactive protein (CRP) is a predictor of cardiovascular risk, but its influence on outcomes after coronary artery bypass grafting surgery (CABG) is still incompletely studied. We studied the association between preoperative CRP and inhospital death after CABG. Patients with acute or chronic infectious or inflammatory disorders, autoimmune diseases, cancer, and prior cardiac surgery were excluded. Seventy-six patients were studied [27.6% with elevated CRP (>3 mg/l)]. Elevated CRP was more frequently found in patients who died than in those who survived (83.3% vs 17.1%, p=0.003); mean CRP levels were, respectively, 6.5±3.4 vs 2.4±3.5 mg/l (p=0.03). The hazard ratio of death was 11.7 for elevated CRP, and the ROC curve for the discrimination of death with CRP had an area under the curve of 0.82. An improvement to mortality risk prediction following CABG may be offered by the preoperative analysis of CRP.
dc.identifier.citationDe Lorenzo A, Pittella F, Rocha A. Increased preoperative C-reactive protein levels are associated with inhospital death after coronary artery bypass surgery. Inflammation. 2012 Jun;35(3):1179-83.
dc.identifier.doidoi: 10.1007/s10753-011-9426-1. PMID: 22231671.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/277
dc.language.isoen
dc.publisherInflammation
dc.subjectC-reactive proteinen
dc.subjectCoronary artery diseaseen
dc.subjectCoronary artery bypass surgeryen
dc.subject.meshTreatment Outcomeen
dc.subject.meshRisk Factorsen
dc.subject.meshMiddle Ageden
dc.subject.meshMaleen
dc.subject.meshInflammation / pathologyen
dc.subject.meshInflammation / metabolismen
dc.subject.meshHumansen
dc.subject.meshFemaleen
dc.subject.meshCoronary Artery Bypass / mortalityen
dc.subject.meshCardiovascular Diseases / mortalityen
dc.subject.meshC-Reactive Protein / analysisen
dc.subject.meshBiomarkers / blooden
dc.titleIncreased Preoperative C-Reactive Protein Levels Are Associated with Inhospital Death After Coronary Artery Bypass Surgeryen
dc.typeArticle
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