Exercise training improves microvascular function in patients with Chagas heart disease: Data from the PEACH study

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dc.contributor.authorBorges, Juliana Pereira
dc.contributor.authorMendes, Fernanda de Souza Nogueira Sardinha
dc.contributor.authorRangel, Marcus Vinícius Dos Santos
dc.contributor.authorLopes, Gabriella de Oliveira
dc.contributor.authorSilva, Gilberto Marcelo Sperandio da
dc.contributor.authorMazzoli-Rocha, Flavia
dc.contributor.authorSaraiva, Roberto Magalhães
dc.contributor.authorSousa, Andrea Silvestre de
dc.contributor.authorTibirica, Eduardo
dc.contributor.authorMediano, Mauro Felippe Felix
dc.date.accessioned2022-09-06T14:27:25Z
dc.date.available2022-09-06T14:27:25Z
dc.date.issued2021
dc.description.abstractBackground: Chagas heart disease (CHD) impairs the systemic microvascular function. We investigated the effects of exercise training on cutaneous microvascular function among patients with CHD. Methods: Patients from the PEACH study were randomly assigned to a supervised exercise training 3 times/week for 6 months (Trained; n = 10) or a control group (Untrained; n = 8). Both groups underwent evaluation of microvascular function before, and at 3- and 6-months of follow-up. Cutaneous vascular conductance (CVC) was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine (ACh), sodium nitroprusside (SNP) and during post-occlusive reactive hyperemia (PORH). Results: At 3-months of follow-up, no difference was detected between groups in CVC responses to ACh (p = 0.50), SNP (p = 0.26) and HRPO (p = 0.65). However, at 6-months of follow-up, trained vs. untrained patients improved CVC induced by SNP-iontophoresis (0.19 ± 0.10 vs. 0.14 ± 0.15 APU.mmHg-1; p = 0.05) and PORH (0.63 ± 0.15 vs. 0.48 ± 0.18 APU.mmHg-1; p = 0.05). CVC response to ACh-iontophoresis was similar between groups (0.19 ± 0.11 vs. 0.22 ± 0.17 APU.mmHg-1; p = 0.38). Conclusion: Exercise training performed during 6 months improved the cutaneous microvascular function of CHD patients. Further studies evaluating the mechanism involved in this response are warranted.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/210
dc.language.isoen
dc.publisherMicrovascular Research
dc.subjectCardiac rehabilitationen
dc.subjectChagas heart diseaseen
dc.subjectCutaneous vascular conductanceen
dc.subjectEndothelial functionen
dc.subjectMicrovascular flowmetryen
dc.subject.meshTreatment Outcomeen
dc.subject.meshTime Factorsen
dc.subject.meshSkin / blood supplyen
dc.subject.meshRegional Blood Flowen
dc.subject.meshRecovery of Functionen
dc.subject.meshMiddle Ageden
dc.subject.meshMicrocirculationen
dc.subject.meshMaleen
dc.subject.meshHumansen
dc.subject.meshFemaleen
dc.subject.meshExercise Therapyen
dc.subject.meshChagas Cardiomyopathy / rehabilitationen
dc.subject.meshChagas Cardiomyopathy / physiopathologyen
dc.subject.meshChagas Cardiomyopathy / parasitologyen
dc.subject.meshChagas Cardiomyopathy / diagnostic imagingen
dc.subject.meshCardiac Rehabilitationen
dc.subject.meshBrazilen
dc.subject.meshAgeden
dc.titleExercise training improves microvascular function in patients with Chagas heart disease: Data from the PEACH study
dc.typeArticle
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