Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging

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dc.contributor.authorSouza, Elaine G.
dc.contributor.authorDe Lorenzo, Andrea
dc.contributor.authorHuguenin, Grazielle
dc.contributor.authorOliveira, Glaucia M.M
dc.contributor.authorTibiriça, Eduardo
dc.date.accessioned2022-09-14T17:18:19Z
dc.date.available2022-09-14T17:18:19Z
dc.date.issued2014
dc.description.abstractObjectives: The assessment of systemic microvascular reactivity is currently considered to be critical in the stratification of cardiovascular risk. In the present study, we compared skin microvascular function in individuals with early-onset (premature) coronary artery disease (EOCAD, n= 30) with that of age-matched and sex-matched healthy individuals (n =30). Materials and methods Using laser speckle contrast imaging, cutaneous blood flow was assessed in the forearm at rest and during reactivity tests, including postocclusive reactive hyperemia and the iontophoresis of acetylcholine or sodium nitroprusside with increasing currents of 30, 60, 90, 120, 150, and 180 lA for 10-s intervals spaced 1 min apart. Carotid intima–media thickness was evaluated using an ultrasound system and a 7.5MHz ultrasound transducer. Results: The endothelium-dependent skin microvascular vasodilator responses that were induced by both acetylcholine and postocclusive reactive hyperemia were significantly reduced in patients with EOCAD compared with healthy individuals. The vasodilator responses that were induced by sodium nitroprusside were also significantly reduced in individuals with EOCAD. These systemic microvascular alterations were concurrent with increased carotid intima–media thickness in these patients. Conclusion: Laser speckle contrast imaging identifies endothelial-dependent and endothelial-independent microvascular dysfunction in individuals presenting with EOCAD, and thus could be valuable as an early peripheral marker of atherothrombotic disease.en
dc.identifier.citationSouza EG, De Lorenzo A, Huguenin G, Oliveira GMM, Tibiriçá E. Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging. Coronary Artery Disease. 2014; 25(1):23-8.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/279
dc.language.isoen
dc.publisherCoronary Artery Disease
dc.subjectCarotid intima–media thickness,en
dc.subjectEarly-onset coronary artery diseaseen
dc.subjectLaser speckleen
dc.subjectMicrovascular endothelial dysfunctionen
dc.subjectMicrovascular reactivityen
dc.subjectMicrovascular smooth muscle dysfunctionen
dc.subject.meshVasodilator Agents / administration & dosageen
dc.subject.meshVasodilation / drug effectsen
dc.subject.meshSkin / blood supplyen
dc.subject.meshRegional Blood Flowen
dc.subject.meshPredictive Value of Testsen
dc.subject.meshMuscle, Smooth, Vascular / physiopathologyen
dc.subject.meshMuscle, Smooth, Vascular / drug effectsen
dc.subject.meshMiddle Ageden
dc.subject.meshMicrovessels / physiopathologyen
dc.subject.meshMicrocirculation / drug effectsen
dc.subject.meshMaleen
dc.subject.meshLaser-Doppler Flowmetryen
dc.subject.meshIontophoresisen
dc.subject.meshHumansen
dc.subject.meshForearmen
dc.subject.meshFemaleen
dc.subject.meshEndothelium, Vascular / physiopathologyen
dc.subject.meshEndothelium, Vascular / drug effectsen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshCoronary Artery Disease / physiopathologyen
dc.subject.meshCoronary Artery Disease / epidemiologyen
dc.subject.meshCoronary Artery Disease / diagnosisen
dc.subject.meshCase-Control Studiesen
dc.subject.meshCarotid Intima-Media Thicknessen
dc.subject.meshBlood Flow Velocityen
dc.subject.meshAge of Onseten
dc.subject.meshAdulten
dc.subject.meshAdministration, Cutaneousen
dc.titleImpairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imagingen
dc.typeArticle
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