Effect of physical exercise training in patients with Chagas heart disease: study protocol for a randomized controlled trial (PEACH study)

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dc.contributor.authorMendes, Fernanda de Souza Nogueira Sardinha
dc.contributor.authorSousa, Andréa Silvestre
dc.contributor.authorSouza, Fernando Cesar de Castro Cesar
dc.contributor.authorPinto, Vivian Liane Mattos
dc.contributor.authorSilva, Paula Simplicio
dc.contributor.authorSaraiva, Roberto Magalhães
dc.contributor.authorXavier, Sergio Salles
dc.contributor.authorVeloso, Henrique Horta
dc.contributor.authorHolanda, Marcelo Teixeira
dc.contributor.authorCosta, Andréa Rodrigues
dc.contributor.authorCarneiro, Fernanda Martins
dc.contributor.authorSilva, Gilberto Marcelo Sperandio
dc.contributor.authorBorges, Juliana Pereira
dc.contributor.authorTibiriçá, Eduardo
dc.contributor.authorPinheiro, Roberta Olmo
dc.contributor.authorLara, Flávio Alves
dc.contributor.authorHasslocher-Moreno, Alejandro Marcel
dc.contributor.authorBrasil, Pedro Emmanuel Alvarenga Americano
dc.contributor.authorMediano, Mauro Felippe Felix
dc.date.accessioned2022-09-06T16:56:11Z
dc.date.available2022-09-06T16:56:11Z
dc.date.issued2016
dc.description.abstractBackground: The effects of exercise training on Chagas heart disease are still unclear. This study aimed to evaluate the effect of exercise training over functional capacity, cardiac function, quality of life, and biomarkers in Chagas heart disease. Methods: The PEACH study is a superiority randomized clinical trial which will include subjects who meet the following criteria: Chagas heart disease with a left ventricular ejection fraction below 45 % with or without heart failure symptoms; clinical stability in the last 3 months; adherence to clinical treatment; and age above 18 years. The exclusion criteria are: pregnancy; neuromuscular limitations; smoking; evidence of non-chagasic heart disease; systemic conditions that limit exercise practice or cardiopulmonary exercise test; unavailability to attend the center three times a week during the intervention period; and practitioners of regular exercise. The intervention group will perform an exercise training intervention three times per week during 6 months and will be compared to the control group without exercise. Both groups will undergo the same monthly pharmaceutical and nutritional counseling as well as standard medical treatment according to the Brazilian consensus on Chagas disease. The primary outcome is functional capacity based on peak exercise oxygen consumption during cardiopulmonary exercise testing. Secondary outcomes are: cardiac function; body composition; muscle respiratory strength; microvascular reactivity; cardiac rhythm abnormalities; autonomic function; biochemical; oxidative stress and inflammatory biomarkers; and quality of life. Subjects will be evaluated at baseline, and at 3 and 6 months after randomization. Thirty patients will be randomly assigned into exercise or control groups at a ratio of 1:1. Discussion: Findings of the present study will be useful to determine if physical exercise programs should be included as an important additional therapy in the treatment of patients with Chagas heart disease. Trial registration: ClinicalTrials.gov ID: NCT02517632 (registered on 6 August 2015).en
dc.identifier.citationMendes Fde S, Sousa AS, Souza FC, Pinto VL, Silva PS, Saraiva RM et al. Effect of physical exercise training in patients with Chagas heart disease: study protocol for a randomized controlled trial (PEACH study). Trials. 2016 Sep 2;17(1):433
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/220
dc.language.isoen
dc.publisherTrails
dc.subjectCardiac rehabilitationen
dc.subjectCardiopulmonary exercise testen
dc.subjectChagas heart diseaseen
dc.subjectExercise trainingen
dc.subjectHeart failureen
dc.subject.meshVentricular Function, Leften
dc.subject.meshTreatment Outcomeen
dc.subject.meshTime Factorsen
dc.subject.meshSurveys and Questionnairesen
dc.subject.meshStroke Volumeen
dc.subject.meshResearch Designen
dc.subject.meshRecovery of Functionen
dc.subject.meshQuality of Lifeen
dc.subject.meshHumansen
dc.subject.meshExercise Toleranceen
dc.subject.meshExercise Therapy / methodsen
dc.subject.meshExercise Therapy / adverse effectsen
dc.subject.meshExercise Testen
dc.subject.meshClinical Protocolsen
dc.subject.meshChagas Cardiomyopathy / rehabilitationen
dc.subject.meshChagas Cardiomyopathy / physiopathologyen
dc.subject.meshChagas Cardiomyopathy / diagnosisen
dc.subject.meshCardiac Rehabilitation / methodsen
dc.subject.meshCardiac Rehabilitation / adverse effectsen
dc.subject.meshBrazilen
dc.subject.meshBiomarkers / blooden
dc.titleEffect of physical exercise training in patients with Chagas heart disease: study protocol for a randomized controlled trial (PEACH study)en
dc.typeArticle
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