COVID-19 and Microvascular Disease: Pathophysiology of SARS-CoV-2 Infection With Focus on the Renin-Angiotensin System

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dc.contributor.authorKasal, Daniel Arthur
dc.contributor.authorLorenzo, Andrea De
dc.contributor.authorTibiriçá, Eduardo
dc.date.accessioned2022-09-09T12:27:21Z
dc.date.available2022-09-09T12:27:21Z
dc.date.issued2020
dc.description.abstractThe recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people, with thousands of fatalities. It has prompted global efforts in research, with focus on the pathophysiology of coronavirus disease-19 (COVID-19), and a rapid surge of publications. COVID-19 has been associated with a myriad of clinical manifestations, including the lungs, heart, kidneys, central nervous system, gastrointestinal system, skin, and blood coagulation abnormalities. The endothelium plays a key role in organ dysfunction associated with severe infection, and current data suggest that it is also involved in SARS-CoV-2-induced sepsis. This critical review aimed to address a possible unifying mechanism underlying the diverse complications of COVID-19: microvascular dysfunction, with emphasis on the renin-angiotensin system. In addition, research perspectives are suggested in order to expand understanding of the pathophysiology of the infection.
dc.identifier.citationKasal DA, De Lorenzo A, Tibiriçá E. COVID-19 and Microvascular Disease: Pathophysiology of SARS-CoV-2 Infection With Focus on the Renin-Angiotensin System. Heart Lung Circ. 2020;29(11):1596-1602.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/222
dc.language.isoen
dc.publisherHeart, Lung and Circulation
dc.subjectCOVID-19en
dc.subjectMicrocirculationen
dc.subjectRenin-angiotensin systemen
dc.subject.meshSARS-CoV-2en
dc.subject.meshRenin-Angiotensin System / physiologyen
dc.subject.meshPneumonia, Viral / physiopathologyen
dc.subject.meshPneumonia, Viral / metabolismen
dc.subject.meshPandemicsen
dc.subject.meshMicrovessels / virologyen
dc.subject.meshMicrovessels / physiopathologyen
dc.subject.meshMicrovessels / metabolismen
dc.subject.meshHumansen
dc.subject.meshCoronavirus Infections / physiopathologyen
dc.subject.meshCoronavirus Infections / metabolismen
dc.subject.meshCOVID-19en
dc.subject.meshBetacoronavirus / physiologyen
dc.titleCOVID-19 and Microvascular Disease: Pathophysiology of SARS-CoV-2 Infection With Focus on the Renin-Angiotensin System
dc.typeArticleen
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