Peak oxygen uptake after the 80s as a survival predictor

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dc.contributor.authorBraga, Fabricio
dc.contributor.authorMilani, Mauricio
dc.contributor.authorFachetti, Ana
dc.contributor.authorEspinosa, Gabriel
dc.contributor.authorMoraes, Gabriel
dc.contributor.authorMilani, Juliana Goulart Prata Oliveira
dc.contributor.authorMourilhe-Rocha, Ricardo
dc.date.accessioned2025-02-06T14:19:52Z
dc.date.available2025-02-06T14:19:52Z
dc.date.issued2024
dc.description.abstractPurpose: Peak oxygen uptake (VO2peak) is a crucial health marker, extensively studied in adults for its prognostic value. However, its significance in the older persons, especially octogenarians, remains underexplored due to limited representation in research. This study aims to assess the predictive power of VO2peak for survival in individuals aged 80 and above. Methods: We included individuals aged 80 or older who underwent cardiopulmonary exercise tests at a single center. Mortality rates were compared based on VO2peak relative to 80% of predicted values (%VO2peak). We employed three multivariate Cox regression models: Model 1 (unadjusted), Model 2 (adjusted for age) and Model 3 (adjusted for age and stroke). Results: Among 188 participants (mean age 83.3 ± 3 years, 68.9% male), 22 (11.7%) passed away during a median follow-up of 494 days. Non-survivors tended to be older with lower VO2peak and %VO2peak. All models demonstrated associations between %VO2peak ≤ 80% and mortality: HR = 3.19 (95% CI: 1.30-7.86, p = 0.011) for M1; HR = 3.12 (95% CI: 1.26-7.74, p = 0.013) for M2 and HR = 2.80 (95% CI: 1.11-7.06, p = 0.028) for M3. Conclusion: In the context of an aging population, this study underscores the enduring significance of VO2peak as a survival predictor among the older person, including octogenarians. These findings carry profound implications for tailoring healthcare strategies to address the evolving demographic landscape.
dc.identifier.citationBraga F, Milani M, Fachetti A, Espinosa G, Moraes G, Milani JGPO, Mourilhe-Rocha R. Peak oxygen uptake after the 80s as a survival predictor. Eur Geriatr Med. 2024 Jun;15(3):807-815. doi: 10.1007/s41999-024-00949-4.
dc.identifier.otherDOI: 10.1007/s41999-024-00949-4
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/806
dc.language.isoen
dc.publisherEuropean Geriatric Medicine
dc.subjectCardiopulmonary exercise testen
dc.subjectCardiorespiratory fitnessen
dc.subjectExercise testen
dc.subjectOctogenariansen
dc.subjectSurvival analysis.en
dc.titlePeak oxygen uptake after the 80s as a survival predictor
dc.typeArticle
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