Divisão de Pesquisa

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https://dspace.inc.saude.gov.br/handle/123456789/18

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Navegando Divisão de Pesquisa por Autor "Barbosa, Rosa Célia Pimentel"

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    Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
    (Pediatric Cardiology, 2024) Innocenzi, Adriana; Rangel, Isabela; Póvoa‐Corrêa, Mariana; Parente, Daniella Braz; Perez, Renata; Rodrigues, Rosana Souza; Fukuyama, Lúcia Tomoko; Barroso, Julia Machado; Oliveira Neto, Jaime Araújo; Sousa, Andréa Silvestre de; Luiz, Ronir Raggio; Barbosa, Rosa Célia Pimentel; Camargo, Gabriel Cordeiro; Moll‐Bernardes, Renata
    The abnormal hemodynamics in Fontan circulation due to persistently increased systemic venous pressure results in hepatic venous congestion and Fontan-associated liver disease. Combined assessment of cardiac and liver fbrosis and cardiac remodeling using multiparametric MRI in this context have not been fully explored. To evaluate cardiac and liver fbrosis and cardiac remodeling using multiparametric MRI in patients who have undergone Fontan procedures. Thirty-eight patients and 23 controls underwent cardiac and liver MRI examinations in a 3.0-T scanner. Mann–Whitney, Fisher exact test, and Spearman’s correlation were applied to evaluate myocardial volumes, function, native cardiac and liver T1 mapping, ECVs and liver stifness. The mean native cardiac T1 value (p=0.018), cardiac ECV (p<0.001), liver native T1 (p<0.001), liver ECV (p<0.001), and liver stifness (p<0.001) were higher in patients than controls. The indexed end-diastolic volume (EDVi) correlated with the myocardial ECV (r=0.356; p=0.033), native liver T1 (r=0.571; p<0.001), and with liver stif- ness (r=0.391; p=0.015). In addition, liver stifness correlated with liver ECV (r=0.361; p=0.031) and native liver T1 (r=0.458; p=0.004). An association between cardiac remodeling and cardiac and liver fbrosis were found in this population. The usefulness of MRI to follow cardiac and liver involvement in these patients is critical to improve treatment strategies and to prevent the need for combined liver and heart transplantation.